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When considering which symptoms necessitate immediate attention from an ophthalmic perspective, the combination of pain and loss of vision is particularly concerning. Pain in the eye may indicate an underlying serious condition such as acute glaucoma, corneal ulcer, or other significant ocular pathology. Loss of vision is similarly alarming, as it can be indicative of serious issues such as retinal detachment, central retinal artery occlusion, or other critical conditions that could lead to permanent visual impairment if not addressed promptly.

The other symptom sets, while they may warrant attention, do not indicate the same level of urgency. Itching and redness could result from minor irritations or allergies and typically do not require emergency intervention. Blurred vision and floaters can be problematic as well, but they are often less acute and can sometimes be managed with routine follow-up rather than immediate care. Light sensitivity and night blindness also indicate potential vision issues, but neither typically constitutes an emergency scenario on the same level as pain and loss of vision, which are classic red flags in ophthalmology.